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Third trimester placentas of SARS‐CoV‐2‐positive women: Histomorphology, including viral immunohistochemistry and in situ hybridization

Histopathology Jul 25, 2020

Smithgall MC, Liu‐Jarin X, Hamele‐Bena D, et al. - This study was sought to compare placentas from SARS‐CoV‐2‐positive and negative women in the hospital in New York City, which became the epicenter of the COVID‐19 pandemic in March 2020. Researchers histomorphologically analyzed 51 singletons, third‐trimester placentas from SARS‐CoV‐2‐positive women, and 25 singletons, third‐trimester placentas from SARS‐CoV‐2‐negative women applying the Amsterdam Criteria as well as with in‐situ hybridization (ISH) and/or immunohistochemistry (IHC). They also noted corresponding clinical findings and neonatal outcomes. This study demonstrated that third trimester placentas were more likely to display evidence of maternal/fetal vascular malperfusion; nevertheless, there was no evidence of direct viral involvement or vertical transmission by ISH and IHC.

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