Stahlie EHA, van der Hiel B, Bruining A, et al. - Despite the presence of high-risk primary tumors in stage IIB/IIC (8th AJCC) melanoma patients, they follow the same routine to sentinel lymph node biopsy (SLNB) as more low risk tumors. Researchers conducted this pilot study investigating the value of ultrasound (US) and 18F-FDG PET/CT prior to lymphoscintigraphy (LSG) and SLNB for stage IIB/C melanoma patients. From April 2019 to January 2020, US of the regional lymph nodes and whole body 18F-FDG PET/CT were performed in all stage IIB/C melanoma patients prior to their planned LSG and SLNB. Screening was performed in total 23 patients: metastases were detected in six patients by imaging, in two patients by US, in one patient by 18F-FDG PET/CT and in three by both imaging modalities. Observations suggest that the presence of SN metastases can not be excluded by preoperative negative imaging, hence SLNB cannot be foregone. However, US resulted in detection of metastases in 22% of patients, altering their treatment, which indicates its effectiveness in the work-up of stage IIB/C melanoma. Further, there appeared no added value of staging with 18F-FDG PET/CT prior to LSG and SLNB and hence its use is not supported.