Stansfield R, et al. - By performing a literature review and descriptive analysis, researchers focused on the use of TXA for hemorrhage management in trauma patients in the prehospital environment. They identified 14 full journal articles that satisfied the inclusion criteria, by performing an extensive literature exploration. A thorough analysis of these articles revealed the following themes: “dose of TXA administration,” “route of TXA administration,” “optimal window of TXA administration,” “safety of TXA use,” “clinical effectiveness of TXA use,” and the “feasibility of TXA application in the prehospital setting.” Findings from literature analysis revealed that a loading dose of 1 g of TXA, followed by 1 g infusion over 8 h, administered by intravenous route within a 3-h window period of traumatic injury affords the best possible outcomes. Findings showed excellent effectiveness as well as safety of TXA for use in the prehospital setting, as well as clinical and economical feasibility of its use.