Agarwala A, et al. - Given cardiovascular disease (CVD) is known as the foremost reason of mortality among women in the United States, and there is a less likelihood of women being diagnosed properly, receive preventive care, or be managed aggressively for CVD, relative to men, and gender disparities between men and women have permitted for the recognition of CVD risk factors and risk markers that are unique to women, so, researchers focused on the use of sex-specific factors in the evaluation of women’s cardiovascular risk. The idea of risk-enhancing factors that are particular to females and are related to a raised risk of incident atherosclerotic CVD in women was proposed by the 2018 American Heart Association/American College of Cardiology Multi-Society cholesterol guideline and 2019 American College of Cardiology/American Heart Association guideline on the primary prevention of CVD. More intensified lifestyle interventions, as well as thought of commencing or intensifying statin therapy for primary prevention to alleviate the heightened risk, would be favored by these factors if present. Here, experts highlight gender-specific CVD risk factors in females, emphasize the significance of obtaining a thorough obstetrical and gynecological history during cardiovascular risk evaluation, and afford a framework for how to start suitable preventive measures when gender-specific risk factors are present.