Lorking N, et al. - Via performing this review, researchers sought to critically examine the literature from 2016 to 2021 using positron emission tomography–magnetic resonance imaging (PET/MRI) for the investigation of patients with mild cognitive impairment or dementia. In addition, they discussed the evidence base for widening its application into clinical practice. A comprehensive literature search using the PubMed database led to the retrieval of a total of 116 papers; 39 of these papers were included in the final selection. Per findings, PET/MRI provides additional information concerning the underlying anatomical, metabolic and functional changes linked with dementia when compared with unimodal methods and PET/CT, particularly relating to brain regions including the hippocampus and default mode network. In addition, PET/MRI has improved diagnostic utility, as described by radiologists, which allows improved classification of dementia patients, with important implications for clinical management.