Lambeck J, Kesenheimer EM, Kleinmann B, et al. - Since the tourniquet ischemia test (IT) is rarely used for the diagnostic work‐up of patients with suspected complex regional pain syndrome (CRPS), researchers sought to determine its sensitivity and specificity, as well as the factors that can influence the test result. Between 2000 and 2011, consecutive data on clinical presentation, results of the IT and other diagnostic tests, and clinical features from 78 patients presenting at the autonomic laboratory were evaluated. Age, gender, the type and stage of CRPS, and the affected extremity had no statistically significant impact on the test result. For CRPS diagnosis, a positive tourniquet IT has a high positive predictive value. As a result, it can be used as a confirmatory assay in patients with suspected CRPS. Because of its low sensitivity, it cannot be used as a screening test. Results indicated a test sensitivity of 49% and a specificity of 88%, with a positive predictive value of 85% and a negative predictive value of 56%.