Shaghaghi MA, et al. - This research was designed to ascertain the substrate(s) for the glucose transporter member 14 (GLUT14) protein and interrogated genetic associations of solute carrier family 2 member 14 (SLC2A14) with inflammatory bowel disease (IBD). The findings reinforced the hypothesis that genetically determined local dysregulation of dietary vitamin C or antioxidants transport contributed to IBD development. By dietary interventions, these transporter proteins were targetable, opening the avenue to a precision intervention for patients with specific genotypes with IBD.