Low S, et al. - In 2013-2016, 4,109 subjects without baseline type 2 diabetes mellitus(T2DM) partook in a community screening program to investigate the role of triglyceride-glucose (TyG) in development of T2DM and the mechanism for the relationship. Cox proportion-hazard model was used to evaluate the risk of T2DM by TyG quartiles at baseline. Researchers performed binary mediation analysis to examine the extent of mediation by TyG between body mass index (BMI) and T2DM development. Compared to quartile 1 of TyG, risk of T2DM incidence increased with quartiles 2, 3 and 4. In clinical practice, TyG was potentially helpful for predicting T2DM. Findings revealed that it was a potential mediator of connection between BMI and T2DM development.