Kremers SHM, Remmelzwaal S, Schalkwijk CG, et al. - In the present study, the researchers sought to examine the correlation of serum and dietary advanced glycation endproducts (AGEs) with cardiac function and structure after eight years of follow-up. Three hundred seventy Hoorn Study candidates (aged 66.4 ± 6.1, 47% women) were included. At baseline and after 8 years of follow-up, they measured serum protein-bound AGEs [N ^ε -(carboxymethyl)lysine, N ^ε -(carboxyethyl)lysine, and pentosidine], as well as echocardiography to evaluate left atrium volume index, left ventricle ejection fraction (LVEF), and left ventricle mass index. The authors discovered a stronger, non-significant, association between higher dietary (carboxyethyl)lysine and higher LVEF at follow-up in participants without cardiovascular disease (CVD) vs participants with CVD. Overall serum AGEs were longitudinally linked to impaired systolic function.