Imagama S, Ando K, Kobayashi K, et al. - A total of 1,128 people who attended an annual health checkup in Yakumo study were included to examine low back pain (LBP) and neuropathic pain (NeP); spinal alignment and range of motion (ROM); spinal degenerative modifications in plain radiography; osteoporosis; muscle strength; and physical ability as probable risk factors for poor quality of life (QOL). In 113 people, NeP was present. In comparison with NeP (–) individuals, significantly more severe pain, slower gait speed, greater osteoporosis rate, lumbar kyphosis, and bigger spinal inclination was noted in the NeP (+) individuals. On a 36-item short-form health survey, for NeP (+) individuals, physical and mental QOL was significantly lower. In multivariate logistic regression analysis adjusted for age and gender, for low physical QOL, NeP (+), positive spinal inclination, and high VAS for LBP were recognized as risk factors, and NeP (+) was the only important risk factor for low mental QOL. Thus, these outcomes imply that in middle-aged and elderly people, interventions for NeP and other recognized risk factors may add to the betterment of low physical and mental QOL.