Huang JW, Xie C, Niu Z, et al. - In view of the prevalence of Helicobacter pylori (H pylori) immunoglobulin G (IgG) seropositivity, researchers here examine its relation with leukocyte telomere length (LTL), a cellular aging biomarker. They used the quantitative polymerase chain reaction to measure LTL in 3,472 participants from the National Health and Nutrition Examination Survey (NHANES) cycle 1999‐2000. Enzyme‐linked immunosorbent assays were used to determine H pylori IgG that was defined as seropositivity with an immune status ratio score > 0.9. In the overall population, H pylori IgG seropositivity was observed in 31.5%; the prevalence was found to be higher in those with older age, other races than non‐Hispanic whites, lower education, and being born out of the United States. Observations suggest no correlation of H Pylori IgG seropositivity with continuous LTL in the general population but possibly with an excessively short LTL in the elderly.