Jansen P, et al. - Researchers studied the clinical value of extirpation of the sentinel lymph node (SLNE) in those with high-risk cutaneous squamous cell carcinoma (hrcSCC) by assessing 114 patients on whom SLNE was done between July 2008 and April 2017. They found a strong relation of histopathological detection of ulceration, perineural growth, and clinically occult SLN metastases with the future occurrence of distant metastases. They noticed a positive predictive value of 50% for subjects where SLN metastasis was identified to develop distant metastases, although distant metastases occurred in seven candidates when no evidence of metastases was recorded while estimating the histopathological SLN. In outpatients with hrcSCC, researchers suggested SLNE was an unreliable diagnostic means to assess risk of future systemic carcinoma spread and development of distant metastases.