Shou J, et al. - Researchers focused on the influence of different distant metastases patterns on the survival of patients suffering from stage IV bladder cancers. For this, they conducted a Surveillance, Epidemiology, and End Results analysis as well as computed overall survival by employing the Kaplan–Meier method. There were 90,382 eligible cases, of these, stage IV bladder cancer accounted for 7.03% (6354/90382) at initial diagnosis. Using multivariate analysis with Cox hazard regression model, metastatic site was shown to be an independent prognostic factor of overall survival in cases with single metastasis. For bladder cancers, the most common site of single metastasis was bone. Worse survival outcome was experienced by patients with liver metastasis vs other three distant metastases. Understanding of these variations in metastatic patterns might aid to better guide pretreatment assessment of bladder cancer and make determination concerning curative-intent interventions.