Wong A, et al. - Given that historically, acetylcysteine has been delivered at a fixed dose and duration of 300 mg/kg over 20 hours to nearly every patient deemed to be at any risk for hepatotoxicity following acetaminophen overdose, researchers examined a 12-hour treatment regimen for selected low-risk patients in this multicenter, open-label, cluster-controlled trial at six metropolitan Emergency Departments. The findings from the present study suggested that discontinuing acetylcysteine based on laboratory testing after 12 hours of treatment was feasible and likely safe in selected patients at very low risk of liver injury from acetaminophen overdose.