Guzman VA, Cham H, Gutierrez J, et al. - The findings show linear longitudinal relations for BP and hypertension (HTN) with poorer neurocognitive (NC) test performance, especially in psychomotor and executive functions in persons with HIV.

• The Manhattan HIV Brain Bank, a prospective, observational, longitudinal study of neuroHIV, collected medical, NC, and virologic data from 485 HIV+ patients.

• Data reported that the baseline prevalence of HTN was 23%.

• Longitudinal variations in diastolic and systolic BP were related to a 10.5-second and 4-second increase in the Grooved Pegboard Test nondominant hand performance, respectively.

• A 0.3-point decrease in correct categories and a 3-point increase in perseverative replies and total errors on the Wisconsin Card Sorting Test were similarly associated with a change in diastolic BP over time.

• On the Wisconsin Card Sorting Test, increasing odds of prevalent and/or incident HTN were associated with a 0.1-point decrease in correct categories and a 0.8-point rise in total mistakes.

• There was no relationship found between pulse pressure and NC performance.