Redondo MJ, et al. - The researchers sought to determine the role and impacts on age of type 2 diabetes–associated genetic factors (eg, gene variants at transcription factor 7-like 2) and obesity (via insulin resistance, inflammation, β-cell stress, or all three) in the pathogenesis of type 1 diabetes at diagnosis. Through the impact of the genetic factors on β-cell function and insulin sensitivity linked with metabolic outcomes an interaction with the immune system to amplify the autoimmune response could be possible. Contributing to disease heterogeneity along with the presence of factors that both forms of diabetes share were noted. Affecting disease prediction, prevention, diagnosis, and treatment, the recognition that type 1 diabetes could result from the sum of effects from islet autoimmunity and type 2 diabetes–associated factors, their interactions, or both were concluded.