Hou M, et al. - In rat maxillae, researchers assessed the influence of systemic zoledronate administration on the osseointegration of titanium implants with different surface topography. For this investigation, 20 Sprague-Dawley rats were divided into two groups—test (bisphosphonate) and control (healthy). According to the findings, systemic zoledronate administration negatively affects osseointegration. In both the presence and absence of systemic zoledronate administration, osseointegration was enhanced adjacent to moderately rough compared to turned implants. Topographic surface modification can therefore partly offset the adverse effect of administration of zoledronate.