Nseir S, Zeineh N, Capucha T, et al. - Since lymph node (LN) density, defined as the number of positive LNs divided by the total number of resected LNs, is considered an important prognostic factor in oral squamous cell carcinoma (OSCC), however, the cut-off point remains unknown, researchers conducted this retrospective study to analyze the influence of LN density as a predictive factor for survival and recurrence of oral tongue squamous cell carcinoma (OTSCC). Between 2008 and 2018, 104 patients underwent a glossectomy procedure for OTSCC. LN density and other related prognostic factors, including pathological N-stage, extranodal extension, perineural invasion, and depth of invasion, were examined in relation to survival and recurrence rates. According to the statistical analysis, the cut-off point for LN density is 2.5%. LN density, in addition to other previously known prognostic factors, may be a strong predictor of survival and recurrence in patients with advanced- and early-stage OTSCC.