Habib G, et al. - Authors assessed the effect of intra-articular corticosteroid injection (IACI) of depot betamethasone at the knee joint on insulin resistance (IR). After consent, they documented the demographic, clinical, and laboratory parameters in addition to fasting blood glucose (FBG) and fasting blood insulin levels just prior to IACI of 1 mL of depot betamethasone. Findings suggested an association of intra-articular corticosteroid injection of betamethasone at the knee joint among patients with diabetes with a significant increase in IR levels vs baseline levels, 1 day following the injection. Compared to the mean percentage for FBG levels, the mean percentage of increase in IR was higher.