Gareton A, Tauziede-Espariat A, Dangouloff-Ros V, et al. - This study was undertaken to evaluate whether the histomolecular criteria established for adult anaplastic pilocytic astrocytoma do not apply to the pediatric population. Researchers conducted an integrative work on the largest pediatric cohort of pilocytic astrocytoma with anaplastic features, determined according to strict criteria: morphology compatible with the diagnosis of pilocytic astrocytoma (PA), with or without necrosis, ≥ 4 mitoses for 2.3 mm2, and MAPK pathway alteration. In this study, 31 tumors were subjected to clinical, imaging, morphological and molecular analyses, including DNA methylation profiling. The results of this research demonstrated that the diagnostic histomolecular criteria established for anaplasia in adult pilocytic astrocytoma (PA) are not of diagnostic or prognostic value in a pediatric setting.