Duarte-García A, Pham MM, Crowson CS, et al. - On the basis of comprehensive individual medical records review, an inception cohort of patients with incident antiphospholipid syndrome (APS) in 2000–2015 from a geographically well-defined population was recognized by the researchers in order to predict the annual incidence and prevalence of and frequency of mortality correlated with APS. Thirty-three cases of incident APS, as described by the Sydney criteria, were recognized among this cohort in 2000–2015. In adults aged ≥ 18 years, the annual incidence of APS was 2.1 per 100,000 population. Incidence rates were comparable in both sexes. The predicted prevalence of APS was 50 per 100,000 population and was comparable in both sexes. Concurrent diagnosis of systemic lupus erythematosus was observed in six patients. Deep vein thrombosis was the most prevalent clinical sign. Among patients with APS, the overall frequency of mortality did not significantly vary from that in the general population. Therefore, the APS occurrence was noted in ~2 persons per 100,000 population per year. The predicted prevalence was 50 per 100,000 population. Moreover, overall mortality was not distinctly diverse from that perceived in the general population.