Posadas-Sanchez R, et al. - Whether or not there is a relationship between IL-10 gene polymorphisms with the development of premature coronary artery disease (pCAD) and cardiovascular risk factors in Mexican individuals was investigated. The IL-10-1082 A/G (rs1800896) G allele was shown to be related to a decreased risk of developing pCAD. The polymorphisms analyzed in patients and controls [-592C/A (rs1800872), -819C/T (rs1800871), and -1082 A/G (rs1800896)] were associated with cardiovascular risk factors. Although in pCAD patients the IL-10 plasma levels were higher, they were not associated with the genotypes of the polymorphisms examined.