Yamaguchi D, Hidaka H, Matsunaga T, et al. - Researchers conducted this multi‐center, randomized, observer‐blinded, non‐inferiority study to compare the effectiveness, tolerability, and safety of the combination of elobixibat and 1 L of polyethylene glycol formulation containing ascorbic acid (PEG‐Asc) solution vs the combination of sodium picosulfate and 1‐L PEG‐Asc solution as bowel preparation for colonoscopy. The sample consisted of 210 outpatients who were randomly assigned to one of two groups: elobixibat plus 1‐L PEG‐Asc group (group A) or sodium picosulfate plus 1‐L PEG‐Asc group (group B). Finally, data from 196 patients (99 in group A and 97 in group B) were analyzed. The bowel preparation time in group A was comparable to that in group B, but sleep disturbance was significantly less common in group A than in group B. Because of the equivalent bowel cleansing effect and less frequent sleep disruption, the combination of elobixibat and 1‐L PEG‐Asc can be considered an alternative bowel preparation for colonoscopy.