Sen E, Elgin U, Ozen O, et al. - This retrospective study compared the bleb morphology and tear tests of glaucoma patients who used trehalose and those who did not after primary trabeculectomy with mitomycin C (MMC) during the early postoperative period. Two groups were included in this analysis: Group 1 using Trehalose + hyaluronic acid (THA) after primary trabeculectomy with MMC (n = 19) and Group 2 undergoing primary trabeculectomy with MMC (n = 16). The preoperative and postoperative intraocular pressure (IOP), the consequences of Schirmer, and tear break-up time tests have been analyzed. There was no statistically significant difference between groups in preoperative IOP, Schirmer test, or tear break-up time. Trehalose use improved the surgical success of primary trabeculectomy with MMC in terms of IOP control, postoperative complications, and bleb morphology in the early postoperative period. Trehalose may aid in wound healing, resulting in an ideal bleb.