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The efficacy and safety of intrathecal dexmedetomidine for parturients undergoing cesarean section: A double-blind randomized controlled trial

BMC Anesthesiology Aug 07, 2020

Li X, Li Y, Lv X, et al. - Researchers investigated the efficacy and safety of intrathecal dexmedetomidine (DEX) for parturients undergoing cesarean section in order to present more data evidence for intrathecal applications. They randomly assigned 300 parturients undergoing cesarean section under spinal anesthesia into three groups: group B: 9.0 mg (1.2 ml) of 0.75% bupivacaine with saline (1 ml); group FB: 9.0 mg (1.2 ml) of 0.75% bupivacaine with 20 μg of fentanyl (1 ml); group DB: 9.0 mg (1.2 ml) of 0.75% bupivacaine with 5 μg of DEX (1 ml).  Compared with group B, group FB and group DB had significantly prolonged duration of sensory block. Group DB had significantly higher overall score of quality recovery than that observed in group FB and group B. Umbilical artery and umbilical vein had low plasma concentration of DEX that cannot be detected. These findings suggest that DEX is a potential local anesthetic adjuvant that the intrathecal combination of 5 μg DEX can safely show a facilitatory block effect and enhance parturients’ recovery quality.

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