Li Z, Li Z, Cheng K, et al. - By performing this systematic review and meta-analysis, researchers assessed impact as well as safety of multimodal cocktail protocols applied with or without glucocorticoids on periarticular infiltration analgesia (PIA) in patients receiving total knee arthroplasty (TKA). PubMed, Medline, Embase, and Cochrane Library databases were explored to identify randomized controlled trials on glucocorticoids as a component of the cocktail protocol employed in PIA for TKA patients. Findings demonstrated effectiveness of glucocorticoid supplementation in PIA and also it did not increase complications or side effects for those with either unilateral or bilateral TKA. Triamcinolone acetonid could be advised in multimodal cocktail protocols for glucocorticoid supplementation.