Limaye NS, et al. - This study sought to provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors. Researchers performed a systematic review to search MEDLINE, EMBASE, and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke. Nine studies including a total of 215 patients were included in this study. BDNF, IGF-1, and VEGF can be significantly increased by AE across different AE protocols in stroke survivors. Nevertheless, there is a need for future studies to ascertain the optimal exercise intensity and modalities, particularly in acute and subacute stroke survivors, and how this may relate to functional outcomes.