Hung CH, Lin YC, Chang YH, et al. - Using Taiwan Longitudinal Health Insurance Database 2005, researchers assessed breast cancer risk in correlation with NSAIDs exposure in female patients (older than 18 years of age) with autoimmune disease (AD). Following 1: 1 individual matching, there were 12,331 NSAID users and 12,331 non-NSAID users who were analyzed. The probability of developing breast cancer was less among NSAID users vs the non-NSAID users, even when NSAIDs with low cumulative defined daily doses were used. Users of selective cyclooxygenase 2 inhibitors, diclofenac, ibuprofen and piroxicam exhibited a significantly reduced incidence of new-onset breast cancer among NSAID users. Overall, a reduced risk of breast cancer was reported in female AD patients in relation to NSAID exposure.