Morcillo S, et al. - This paper scrutinized the results of different studies (2012–2017) concerning the effect of metabolic and bariatric surgery (MBS) on DNA methylation patterns (the most studied epigenetic marker) and its association with metabolic improvement. As per observations, the DNA methylation profile of different genes can be modified by metabolic and bariatric surgery and it contributes to the metabolic health benefits that are often seen after metabolic and bariatric surgery.