Nusbaum DJ, Marks SF, Marks MBF, et al. - The present study was sought to assess reproductive outcomes in men undergoing vasectomy reversal (VR) aged ≥ 50 vs < 50 years. Researchers assessed reproductive outcomes (obstructive interval, female age, anastomosis type, post-VR total motile count, and pregnancy) after VR for men aged < 50 and ≥ 50 years. The Kruskal-Wallis rank sum or Chi-squared tests were applied to conduct Statistical analysis. They applied Multiple logistic regression to distinguish factors correlated with achieving pregnancy. They enrolled a sum of 2,777 men < 50 years and 353 men ≥ 50 years. It was shown that more men < 50 years achieved a pregnancy after VR in comparison with those ≥ 50 years. Nevertheless, on adjusted multivariable analysis, age at VR was not an independent prognosticator of achieving pregnancy. While a history of smoking was associated with decreased odds, shorter obstructive interval, and female age were correlated with achieving pregnancy. After VR, successful outcomes can be achieved in older men, and VR should be considered in men ≥ 50 years when conducted by a trained microsurgeon.