The effect of hemostatic agents on early healing of the extraction socket
Journal of Clinical Periodontology May 05, 2019
Guo X, et al. - This analysis focused on the impact of two commercially available hemostatic agents (ie, collagen sponge and oxide cellulose) on early healing of the extraction socket. Bilateral maxillary first molars were extracted in a murine model and the sockets were filled with or without hemostatic agents. In vitro studies have also been designed to examine the effect of agents on pH dynamics and cell viability. Both agents delayed early socket healing, but with different patterns. Both materials have delayed the proliferation and osteogenic differentiation of cells. In addition, apoptosis of periodontal ligament cells occurred in the groups of hemostatic agents. Both agents attribute these effects to the compression of the periodontal ligament, the acidic niche caused by oxide cellulose, and the agents' intense external body reaction and inflammatory response. Overall, the authors concluded that placing hemostatic agents delays early extraction healing through various biological mechanisms.
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