Blauth FG, dos Santos Vilar LA, de Carvalho Brito Pontes V, et al. - Findings demonstrate a substantial impact of frailty on nighttime blood pressure (BP) values and patterns in patients older than 80 years.

• Frailty has an important role in hypertension management in the very elderly and has a strong link with cardiovascular diseases.

• This study included patients older than 80 years; 38 were frail and 36 non-frail (mean age 85.3 ± 3.7 years; 67% females).

• For frail and robust participants, similar were awake systolic and diastolic BP.

• Frail patients exhibited higher systolic BP during sleep (128 ± 15 mm Hg vs 122 ±13 mm Hg) and decreased systolic BP decline [1 (-4.5 – 5)% vs 6.8 (2.1 – 12.8)%].

• An independent association of frailty with higher risk of non-dipping (OR 12.4) and decreased nighttime systolic BP fall (-6.1%) was found.