Turk B, et al. - Authors assessed the analgesic effectiveness and safety of oral spray form of flurbiprofen in the treatment of postoperative pain in tonsillectomy patients. Flurbiprofen spray added to oral ibuprofen demonstrated to be efficacious in the management of postoperative pain with no notable complications.

Methods

• Researchers conducted an open, randomised, controlled clinical study at a tertiary care training and research hospital.
• They included 100 participants (53 males, 47 females) with an age range of 18-53 years old (mean 27.4 ± 9.3 SD) undergoing tonsillectomy in this prospective controlled study.
• The study group included patients (53) receiving oral ibuprofen and flurbiprofen as spray, whereas patients receiving only oral ibuprofen were enrolled as control group (47) in postoperative period.
• Visual analogue scale was used to evaluate the postoperative pain on 12th hour, first, third and seventh days after surgery.

Results

• Findings suggested that the patients who had received flurbiprofen spray and ibuprofen, their mean maximal pain score of was 3.36 ± 1.93 SD.
• This score was statistically lower than the mean maximal pain score of patients who were medicated with only ibuprofen which was 4.06 ± 1.29 SD on postoperative seventh day (P=.013).