Odun-Ayo, F et al. - The impact of clusterin (CLU) and glutathione-s-transferase (GST) in the urine of pre-eclamptic pregnant women with HIV infection are ascertained in this study. The current study showed that the HIV infection influences the activity of urinary CLU protein thereby exacerbating the pathophysiology of Pre-eclampsia (PE). However, the strong correlation exhibited between urinary CLU and GST, implicates the cytoprotective role of these proteins, to neutralize the oxidative radicals or immune hyper-reactivity related to PE development through complement response in HIV infection. Further studies examining the complex interactions between CLU and HIV; its predictive role in HIV infected PE is required.