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The effect of atorvastatin on inflammatory markers in sulfur mustard gas induced bronchitis: A randomized double-blinded, placebo-control clinical trial

BMC Pulmonary Medicine Apr 07, 2021

Momeni B, Nazer S, Masoompour SM, et al. - Researchers undertook this randomized double-blinded clinical trial to assess atorvastatin’s anti-inflammatory impact in patients suffering from chronic bronchitis, exposed to sulfur mustard gas. Participants were 90 males 45–75 years old who received a diagnosis of chronic bronchitis post-exposure to mustard gas during the Iran-Iraq war. These individuals were randomized to receive either atorvastatin (40 mg) or placebo once a day for 3 months. Experts compared interleukin 6, tumor necrosis factor α, procalcitonin, highly sensitive C reactive protein and chronic obstructive pulmonary disease assessment test score at baseline and following 12 weeks. Findings revealed that no significant alteration in inflammatory markers or the quality of life was brought about by treatment with 40 mg atorvastatin for 3 months in patients exposed to mustard gas with chronic bronchitis.

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