Senel T, et al. - Researchers examined whether platelet indices [platelet, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW)] are associated with gastrointestinal bleeding (GIB) as well as its severity and prognosis. They examined 500 patients with GIB who diagnosed with “Gastrointestinal System Bleeding”, as well as 114 healthy individuals in the study. Findings suggest a poor prognosis in correlation to increasing age, female gender, the presence of comorbidities, high levels of platelet indexes, low levels of hemoglobin, and albumin values. PCT, MPV, and PDW were identified to be the independent risk factors that predict the odds of GIB, in addition, they independently predicted the risk of bleeding severity and the prognosis. Findings support a possible utility of platelet indices in the diagnosis of GIB, as well as in predicting bleeding severity and the prognosis.