Shaker M, Chan ES, Protudjer JLP, et al. - Researchers conducted the study for assessing the cost-effectiveness of preschool peanut oral immunotherapy (POIT) in North America. They used Markov cohort analyses and microsimulation to assess simulated preschool children with PA over an 80-year time horizon. A preschool POIT strategy was linked to cost savings while improving quality-adjusted life-years (QALY), dominating a nonimmunotherapy approach. In the United States and Canada, preschool POIT in a real-world setting improved health and economic outcomes.