Hirai H, et al. - In the present study, researchers immunohistochemically assessed the adipophilin (ADP), also known as perilipin 2 or adipose differentiation-related protein, and fatty acid synthase (FASN) expression and investigated their clinicopathological significance in a series of 147 salivary duct carcinomas (SDCs). ADP and FASN were expressed in at least a limited part of the tumor in 146 cases among the 147 SDC tumor specimens. This research demonstrated that ADP and FASN are often but unevenly expressed in SDC. ADP is correlated with histological aggressiveness and has prognostic importance with adverse outcomes of survival in patients with SDC. Therefore, ADP may be a new prognostic predictor and a novel therapeutic target linked to lipid metabolism. Furthermore, FASN may interact biologically with the AR signaling pathway.