Zhang Y, et al. - Researchers evaluated the clinical impacts of laser preparation compared with other types of chemical or mechanical preparation of tooth surfaces used in fissure sealant placement through a systematic review and meta-analysis. No significant difference was found between laser preparation and conventional acid-etching preparation at 3-, 6-, and 12-month follow-ups. There was no significant difference reported in the incidence of caries. And no significant differences between acid-etching and laser preparation were discovered in the heart rate, oxygen saturation, or degree of patient dental anxiety. According to the present limited evidence, lasers can be an effective method of pretreatment. The rate of retention was comparable to that of conventional acid etching. However, there was an overall high risk of bias in the included studies and more rigorous research is required.