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The association of a novel cognitive frailty index and physical functioning in older at-risk adults

Aging and Mental Health Jan 27, 2019

Armstrong NM, et al. - Researchers examined metrics of a newly developed Cognitive Frailty Index (CFI) for their association with objective functional limitations. They analyzed baseline data from 607 participants from the Baltimore Experience Corps Trial with measures on the CFI (mean reaction time [RT] for total, first-half, and second-half trials per condition), a computerized Stroop test, and Short Physical Performance Battery (SPPB) score ≤ 9. Using latent growth models, they created additional CFI metrics of initial level (intercept) and change (slope) in RT across accurate trials by easy (Color-X) and difficult (Color-Word) conditions. Latent growth model approaches seemed the most informative despite a correlation between all CFI RT metrics and SPPB < 9. Findings, thus, showed the interplay of cognitive frailty and worse objective mobility within a sociodemographic at-risk sample.

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