Ye M, et al. - Researchers performed an inhabitant-based cohort study between January 2011 and December 2016 including a healthy population to determine the utility of time-mean serum uric acid (SUA) value as an indicator of the risk of chronic kidney disease (CKD), as well as to see how baseline and time-mean SUA levels are associated with kidney function decline and incident CKD. All participants had baseline estimated glomerular filtration rates (eGFR) > 60 ml/min/1.73 m². They used a multivariate adjusted binary logistic regression analysis and Cox proportional hazards models to assess the risk of newly-developed CKD among different stratified groups. Findings revealed an independent association in the general population of an increased time-mean and single SUA value with an increased likelihood of eGFR decline and new-onset CKD development.