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The association between diabetes mellitus and reduction in myocardial glucose uptake: A population-based 18F-FDG PET/CT study

BMC Cardiovascular Disorders Nov 02, 2018

Hu L, et al. - Researchers ascertained the utility of whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scan for illustrating abnormal myocardial glucose metabolism in diabetes, as well as influencing factors. PET/CT images of 191 subjects were retrospectively analyzed. The levels of FDG uptake in myocardium were visually divided into grades 0–3, from low to high. They analyzed diabetes mellitus (DM), impaired fasting glucose (IFG), and normal fasting glucose (NFG) groups in terms of differences in clinical and metabolic parameters, as well as their associations with myocardial FDG uptake. Findings revealed an association of diabetes with decreased myocardial glucose metabolism, which was mediated by multiple metabolic abnormalities. Independent risk factors for poor myocardial FDG uptake were male gender, HOMA-IR, and nonalcoholic fatty liver disease.

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