Pham MN, Hudnall MT, Fantus RJ, et al. - A retrospective cohort study was conducted with the aim to examine the relationship between stimulant medications used for the treatment of attention deficit hyperactivity disorder and semen parameters.

• Between 2002 and 2020, researchers identified a total of 8,861 men with a semen analysis without prior spermatotoxic medication use, empiric medical therapy exposure or confounding medical diagnoses (varicocele, Klinefelter's syndrome, cryptorchidism, cystic fibrosis, diabetes, cancer or cancer-related treatment, and azoospermia).

• Active prescriptions for stimulants were made within 90 days prior to semen testing in 106 of these men.

• Stimulant use appeared to be linked with reduced total motile sperm count in the setting of decreased semen volume, but not sperm concentration, motility and morphology.

• Reproductive physicians and mental health providers are advised to counsel men on the potential negative impact of stimulants prescribed for attention deficit hyperactivity disorder on semen volume during fertility planning.