Kato A, et al. - The purpose of this study was to determine the role of class III β-tubulin (TUBB3) in determining the efficacy of nab-paclitaxel and gemcitabine (nab-P + Gem) among patients with unresectable pancreatic ductal adenocarcinoma. In specimens obtained by endoscopic ultrasound-guided fine needle aspiration, absence of TUBB3 expression was a favorable predictive marker of the response to nab-P + Gem in the study cohort. Hence, TUBB3 is a potential biomarker for treatment optimization.