Davis TME, et al. – Researchers of this study drew on data from the longitudinal observational Fremantle Diabetes Study Phase II (FDS2) to determine incidence and predictors of severe hypoglycemia in community-based patients who were studied between 2008 and 2013 and compared them with those in a cohort with type 2 diabetes from the same geographical area evaluated a decade earlier. In this analysis, 1,551 participants (mean age, 65.7 years; 51.9% males) with type 2 diabetes were studied. Older age, alcohol consumption, current smoking, higher educational attainment, sulfonylurea/insulin treatment, prior severe hypoglycemia, renal impairment and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) were found to be independent predictors of incident severe hypoglycemia in FDS2. Except for smoking, the same variables were related to the frequency of severe hypoglycemia. They found that the incidence and frequency of severe hypoglycemia did not change between FDS Phases. However, novel risk factors including plasma NT-proBNP were noted in FDS2.