Silva-Gutierrez N, et al. - Researchers intended to determine Th1, Th2, Th17 and Treg polarization, induced by 4 important Toxoplasma gondii (T. gondii) antigens (SAG1, ROP1, GRA8 and MAG1) in acutely and chronically infected patients. In the acute phase, a proinflammatory profile (INF-γ, IL-12 and IL-17) induced by SAG1 and ROP1 was detected whereas in chronically infected patients, a regulatory pattern (Treg and TGF-β) induced by MAG1 and GRA8 was shown. Basic differences in T-cell polarization induced by T. gondii antigens were discovered, the important implications of which in the immunopathogenesis of the disease and in future proposals of therapeutic strategies were suggested.