Vakrakou AG, et al. - The occurrence of aberrant DNA build-up in various biologic compartments of Sjögren's syndrome (SS) patients, as well as its correlation with the activity of NLRP3 [NACHT, LRR and PYD domains-containing protein 3 (NALP3)] and AIM2 (absent in melanoma 2) inflammasomes, was examined by assessing sera, PBMC, circulating monocytes and salivary glands (SG) from different SS patient subgroups and controls. In severe SS, the occurrence of systemic NLRP3 inflammasome activation was shown. This was found to be related to widespread extranuclear accumulations of inflammagenic DNA and impaired DNA degradation.