Kosydar S, Robertson JC, Woodfin M, et al. - Researchers compared photon-based stereotactic radiosurgery (SRS) vs fractionated stereotactic radiotherapy (fSRT) for the treatment of uveal melanoma, focusing on efficacy and adverse event profile. They performed a meta-analysis including 24 articles with a total of 1,745 patients identified from PubMed, Embase, Web of Science, Scopus, and 2 Cochrane databases. Incidence proportions of local control, enucleation, metastatic progression, disease-specific, and overall death were the primary outcomes. Secondary outcomes included treatment-associated toxicities such as incidence proportions of radiation retinopathy, neovascular glaucoma, optic neuropathy, and cataract formation. For all primary, secondary and 5-year outcome measures, including local control, enucleation, and neovascular glaucoma, experts found no statistically significant disparities between photon-based fSRT and SRS. Overall, tumor control, survival and toxicities, as defined herein, did not differ between SRS and fSRT for uveal melanoma. In this analysis of novel management modalities deployed in rare tumors, confounding biases continue to be an expected limitation.