Marasco E, et al. - Herein, researchers investigated JIA patients for the possible correlation between abnormalities in B-cell subsets and clinical features and response to treatment. Compared with healthy children, JIA patients exhibited a faster rate of expansion of switched memory B-cells (SwM B-cells) during disease course. This increase was more evident in early-onset JIA. Notably, in cases with achieved and maintained remission, but not in those with active disease, TNF inhibitors treatment inhibited this increase.