This study among postmenopausal women did not yield evidence to suggest that weight changes in adulthood significantly influence the risk of pancreatic cancer in this population.

• In the US, pancreatic cancer is the fourth leading cause of cancer mortality, and there exists a positive association of obesity with pancreatic cancer risk.

• A total of 136,834 post-menopausal women with 873 incident pancreatic cancer cases in the Women’s Health Initiative were analyzed using the prospective cohort data.

• Relative to women with stable weight, no significant links were identified between steady weight gain (hazard ratio,HR=1.01), sustained weight loss (HR=1.26), or weight cycling patterns (HR=1.08) and pancreatic cancer.

• Findings remained similar when the outcome definition was restricted to pancreatic adenocarcinoma cases.