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Sustained weight loss, weight cycling, and weight gain during adulthood and pancreatic cancer incidence in the Women’s Health Initiative (US)

American Journal of Epidemiology Feb 03, 2022

This study among postmenopausal women did not yield evidence to suggest that weight changes in adulthood significantly influence the risk of pancreatic cancer in this population.

  • In the US, pancreatic cancer is the fourth leading cause of cancer mortality, and there exists a positive association of obesity with pancreatic cancer risk.

  • A total of 136,834 post-menopausal women with 873 incident pancreatic cancer cases in the Women’s Health Initiative were analyzed using the prospective cohort data.

  • Relative to women with stable weight, no significant links were identified between steady weight gain (hazard ratio,HR=1.01), sustained weight loss (HR=1.26), or weight cycling patterns (HR=1.08) and pancreatic cancer.

  • Findings remained similar when the outcome definition was restricted to pancreatic adenocarcinoma cases.

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